Cardiovascular: Check for indications of hypotension, specifically in These whose blood pressure is compromised
Usage of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with Promethazine VC with Codeine Oral Remedy involves mindful thing to consider of the results on the mum or dad drug, codeine, as well as the active metabolite, morphine.
Usually do not acquire 2 doses at the same time or excess doses. Many times promethazine and codeine is taken on an as desired foundation. Will not consider a lot more usually than told from the medical professional.
That will help protect against withdrawal, your health care provider may perhaps reduce your dose gradually. Withdrawal is much more likely For those who have utilised this medication for a very long time (various months) or in higher doses. Inform your medical doctor or pharmacist instantly When you have withdrawal.
Will not consider this medication for numerous times ahead of allergy tests mainly because test benefits can be affected.
Codeine could trigger miosis, even in total darkness. Pinpoint pupils are a sign of opioid overdose but are certainly not pathognomonic (eg, pontine lesions of hemorrhagic or ischemic origin may perhaps produce identical findings). Marked mydriasis rather than miosis might be viewed with hypoxia in overdose situations [see
If your response to an opioid antagonist is suboptimal or only quick in character, administer extra antagonist as directed through the products’s prescribing info. The respiratory depressant effects of promethazine are certainly not reversed by opioid antagonists, such as naloxone.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated.
Signals and indicators of overdosage with promethazine range from delicate despair in the central anxious program and cardiovascular system to profound hypotension, respiratory despair, unconsciousness and sudden Dying.
Stay away from the usage of Promethazine VC with Codeine Oral Solution in patients with head personal injury, intracranial lesions, or perhaps a pre-present rise in intracranial strain. In individuals who may be liable to the intracranial results of CO 2 retention (eg, All those with evidence of enhanced intracranial stress or Mind tumors), Promethazine VC with Codeine Oral Resolution might cut down respiratory generate, and also the resultant CO two retention can more increase intracranial force.
Carcinogenicity, mutagenicity, and fertility experiments haven't been executed with Promethazine with Codeine Oral Remedy; even so, published info is available for the person Lively elements.
Carcinogenicity studies have been executed with promethazine hydrochloride. Two-calendar year research in F344/N rats and B6C3F1 mice have been executed to evaluate the carcinogenic possible of promethazine hydrochloride. here No evidence of tumorigenicity was observed in male and female rats at promethazine hydrochloride oral doses approximately 33 mg/kg/working day for 5 days/week (about reminiscent of ten situations the MRHD on a mg/m2 foundation).
Evaluate liquid doses carefully. Make use of the measuring machine that comes with promethazine and codeine. If there is none, check with the pharmacist for a device to measure promethazine and codeine. What do I do if I miss out on a dose?
Absorption Codeine is absorbed in the gastrointestinal tract with highest plasma focus transpiring sixty minutes post administration. The presence of a higher-Unwanted fat, significant-calorie food didn't noticeably impact the PK of codeine.